MCALBYRNE MCB

MCB

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Career Path:

2007-2010  BSc Biochemistry, University of Leeds
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├── 2011-2015  PhD Studies, University of Bristol
│               └─ X-ray Crystallography, Enzymology
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├── 2016-2021  Postdoctoral Researcher, University of Leeds
│               └─ Kinase Drug Discovery, Cryo-EM
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├── 2021-2023  eBIC Staff Scientist
│               └─ Structural Biology
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├── 2023-2025  Senior Scientist, Exscientia/Recursion
│               └─ Structure-based Drug Discovery
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└── 2025–      eBIC Staff Scientist
                └─ Cryo-EM Software Development

STRUCTURAL BIOLOGIST

INDIE DEVELOPER

A structural biologist and indie developer based in the UK. Combining experimental structure determination, computational protein design, and software development to tackle problems in drug discovery and beyond.

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CryomaskR

CRYOMASKR

WYSIWYG CRYO-EM MASK GENERATION

Wrestling Shuffle

WRESTLING SHUFFLE

MASSIVELY MULTIPLAYER TRADING CARD GAME

SELECTED PUBLICATIONS

Computational design of therapeutic antibodies with improved developability

mAbs • 2025

FA Dreyer, C Schneider, A Kovaltsuk, D Cutting, MJ Byrne, DA Nissley, et al.

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Dynamic assembly of pentamer-based protein nanotubes

ACS Nano • 2025

L Koziej, F Fatehi, M Aleksejczuk, MJ Byrne, JG Heddle, R Twarock, et al.

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The cryoEM structure of the Hendra henipavirus nucleoprotein reveals insights into paramyxoviral nucleocapsid architectures

Scientific Reports • 2024

TC Passchier, JBR White, DP Maskell, MJ Byrne, NA Ranson, et al.

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Structure of the plant plastid-encoded RNA polymerase

Cell • 2024

A Vergara-Cruces, I Pramanick, D Pearce, VK Vogirala, MJ Byrne, et al.

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CryoEM and stability analysis of virus-like particles of potyvirus and ipomovirus infecting a common host

Communications Biology • 2023

O Chase, A Javed, MJ Byrne, EC Thuenemann, GP Lomonossoff, et al.

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Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane

Nature Communications • 2021

Byrne MJ, Iadanza MG, Perez MA, Maskell DP, George RM, Hesketh EL, et al.

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The structure of a plant-specific partitivirus capsid reveals a unique coat protein domain architecture

Communications Biology • 2021

M Byrne, A Kashyap, L Esquirol, N Ranson, F Sainsbury

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A replicating viral vector greatly enhances accumulation of helical virus-like particles in plants

Viruses • 2021

EC Thuenemann, MJ Byrne, H Peyret, K Saunders, R Castells-Graells, et al.

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Nek7 conformational flexibility and inhibitor binding probed through protein engineering

Biochemical Journal • 2020

MJ Byrne, N Nasir, C Basmadjian, C Bhatia, RF Cunnison, KH Carr, et al.

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Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide β-methyl branch incorporation

Scientific Reports • 2020

AV Nair, A Robson, TD Ackrill, M Till, MJ Byrne, CR Back, K Tiwari, et al.

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Combining transient expression and cryo-EM to obtain high-resolution structures of luteovirid particles

Structure • 2019

MJ Byrne, JFC Steele, EL Hesketh, M Walden, RF Thompson, et al.

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A Natural Diels-Alder Biocatalyst Enables Efficient [4+2] Cycloaddition Under Harsh Reaction Conditions

ChemCatChem • 2019

CO Marsh, NR Lees, LC Han, MJ Byrne, SZ Mbatha, L Maschio, et al.

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An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis

Angewandte Chemie • 2019

NR Lees, LC Han, MJ Byrne, JA Davies, AE Parnell, PEJ Moreland, et al.

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Affimer reagents as tools in diagnosing plant virus diseases

Scientific Reports • 2019

EL Hesketh, C Tiede, H Adamson, TL Adams, MJ Byrne, et al.

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The catalytic mechanism of a natural Diels–Alderase revealed in molecular detail

Journal of the American Chemical Society • 2016

MJ Byrne, NR Lees, LC Han, MW Van Der Kamp, AJ Mulholland, et al.

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Improving the success rate of protein crystallization by random microseed matrix screening

Journal of Visualized Experiments • 2013

M Till, A Robson, MJ Byrne, AV Nair, SA Kolek, PDS Stewart, PR Race

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