CryomaskR - Matthew Byrne

Download CryomaskR

↓ macOS DMG For Mac → View on GitHub Source & Releases

About CryomaskR

CryomaskR is a desktop application designed to simplify and streamline the process of creating masks for cryo-electron microscopy (cryoEM) data analysis. Built with a "What You See Is What You Get" (WYSIWYG) philosophy, CryomaskR provides an intuitive interface for structural biologists to generate high-quality masks without the need for complex command-line operations.

Traditional mask generation in cryoEM workflows often involves iterative scripting and visualization cycles. CryomaskR eliminates this friction by providing real-time visual feedback, allowing researchers to interactively create and refine masks while seeing immediate results. This approach significantly reduces the time from data acquisition to structural analysis.

Key Features

Interactive, real-time mask generation with immediate visual feedback
Cross-platform support for macOS and Linux
Integration with standard cryoEM file formats
Intuitive graphical interface requiring no programming knowledge
Advanced masking tools for complex structures and membrane proteins
Export masks compatible with popular cryoEM software packages

Technology Stack

C++ Python Qt Framework OpenGL CryoEM 3D Visualization

FAQ

How do I open CryomaskR on macOS if I get a security warning?

If you see a message that "CryomaskR cannot be opened because it is from an unidentified developer," you can bypass macOS Gatekeeper using one of these methods:

Method 1: Right-click to open

Locate CryomaskR.app in Finder
Right-click (or Control-click) on the app
Select "Open" from the menu
Click "Open" in the dialog that appears

Method 2: Terminal command

Open Terminal
Navigate to where you downloaded CryomaskR
Run: xattr -cr CryomaskR.app
Double-click the app to open normally

Note: Official Apple notarization is in progress. Once complete, these steps will no longer be necessary.

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