Matthew Calthorpe-Byrne

Structural

Biologist &

Enzymologist

Indie Developer

Solving protein structures and having fun doing it. Uncovering the mysteries of protein structure and function. Recent adventures in scientific software development. Hobbyist indie game developer.

Biography

I'm a Scientist at eBIC. Bringing cutting edge cryo-EM access to the UK and Europe. At present my research focuses on cryo-electron microscopy and its adoption in drug discovery.

2025

EM Staff Scientist eBIC

2023

Senior Scientist Exscientia

2021

EM Staff Scientist eBIC

2016

Postdoctoral Researcher Univ. of Leeds

2011

PhD Studies Univ. of Bristol

Structural

Biologist &

Enzymologist

Biography

Software Projects

CryomaskR

Wrestling Shuffle

Scientific Publications

Computational design of therapeutic antibodies with improved developability

Dynamic assembly of pentamer-based protein nanotubes

The cryoEM structure of the Hendra henipavirus nucleoprotein

Structure of the plant plastid-encoded RNA polymerase

CryoEM and stability analysis of virus-like particles of potyvirus and ipomovirus

Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action

The structure of a plant-specific partitivirus capsid

A replicating viral vector greatly enhances accumulation of helical virus-like particles

Nek7 conformational flexibility and inhibitor binding probed through protein engineering

Structure and mechanism of a dehydratase/decarboxylase enzyme couple

Combining transient expression and cryo-EM to obtain high-resolution structures of luteovirid particles

A Natural Diels-Alder Biocatalyst Enables Efficient [4+2] Cycloaddition

An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate Biosynthesis

Affimer reagents as tools in diagnosing plant virus diseases

The catalytic mechanism of a natural Diels–Alderase revealed in molecular detail

Improving the success rate of protein crystallization by random microseed matrix screening

Structural Biologist & Enzymologist

Biography

Software Projects

CryomaskR

Wrestling Shuffle

Scientific Publications

Computational design of therapeutic antibodies with improved developability

Dynamic assembly of pentamer-based protein nanotubes

The cryoEM structure of the Hendra henipavirus nucleoprotein

Structure of the plant plastid-encoded RNA polymerase

CryoEM and stability analysis of virus-like particles of potyvirus and ipomovirus

Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action

The structure of a plant-specific partitivirus capsid

A replicating viral vector greatly enhances accumulation of helical virus-like particles

Nek7 conformational flexibility and inhibitor binding probed through protein engineering

Structure and mechanism of a dehydratase/decarboxylase enzyme couple

Combining transient expression and cryo-EM to obtain high-resolution structures of luteovirid particles

A Natural Diels-Alder Biocatalyst Enables Efficient [4+2] Cycloaddition

An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate Biosynthesis

Affimer reagents as tools in diagnosing plant virus diseases

The catalytic mechanism of a natural Diels–Alderase revealed in molecular detail

Improving the success rate of protein crystallization by random microseed matrix screening

Structural

Biologist &

Enzymologist